More than three months after their fateful crash, the survivors of Oceanic flight 815 will discover that the only thing more dangerous than the island might be the people who have come to rescue them.

A father and his son are two of the last remaining people on earth after an unexplained tragedy has destroyed most of life. As the two head south, they are faced with many trials and tribulations along the way. An intense bond between the father and son is formed as together they strive to not only survive, but to retain humanity as they help the people they encounter along the way.

Ray Ferrier is a working class man living in New Jersey. He has become estranged from his family and his life isn't in order. His small town life is shaken violently by the arrival of destructive intruders: Aliens which have come up from the ground, en masse, to destroy Earth and all the humans living on it. As the aliens plow through the country in a wave of mass destruction and violence, Ray must put aside thoughts of himself and come to the defense...

When a mysterious virus is brought to Earth by a returning satellite, an elite and dedicated squad of scientists assemble to search for the truth and stop the mutating killer before it ends life on Earth.